nELISACLAMPHigh-Throughput
Is This the ELISA 2.0 We've Been Waiting For?
Explore nELISA from Nomic Bio - a 191-plex immunoassay platform using DNA-mediated CLAMP technology with sub-picogram/mL sensitivity across 7 orders of magnitude.
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Advanced Imaging & Multiplexing
7 articles • Revolutionary imaging techniques and applications
Revolutionary imaging techniques using DNA-barcoded conjugates, signal amplification methods, and high-resolution spatial analysis for advanced multiplexed protein detection.
Sprox-seqPLAProtein Interactions
Exploring the Next Frontier: Spatial Proximity Sequencing
Discover Sprox-seq, a breakthrough combining proximity ligation with spatial platforms to map 528 protein-protein interactions in tissue with preserved spatial coordinates.
Fluid-SquidOpen SourceMultiplexing
Can DIY Microscopy Finally Democratize Spatial Biology?
Discover how Fluid-Squid combines open-source microscopy with automated fluidics for affordable 36-plex AOC imaging, making spatial proteomics accessible for around $30k.
L-DNANuclear ImagingInnovation
AOC Techniques Continue to Advance: Solving Nuclear Imaging with Left-Handed DNA
Nuclear imaging presents unique challenges in spatial biology. Learn how left-handed DNA (L-DNA) oligonucleotide conjugates overcome nuclear membrane barriers for improved imaging.
CycIFDNA-BarcodedMultiplexing
Flexible Multiplexed Imaging via Cyclic Immunofluorescence with DNA-Barcoded Antibodies
Advances in spatial proteomics have underscored the need for highly multiplexed imaging platforms that can preserve tissue integrity while enabling comprehensive protein analysis.
SABERIMCSignal Amplification
Amplifying Discovery: How Antibody–Oligo Conjugates Power SABER-IMC
Imaging Mass Cytometry (IMC) has the potential to profile ~40 proteins in tissues but struggles to detect low-abundance markers. The latest advance—SABER-IMC (Signal Amplification By Exchange Reaction for IMC).
IN-DEPTHSpatial BiologyHigh Resolution
IN-DEPTH: IN-situ DEtailed Phenotyping To High Resolution
In the evolving field of biomarker discovery and spatial biology, IN-situ DEtailed Phenotyping To High Resolution (IN-DEPTH) represents a groundbreaking approach for high-dimensional cellular analysis.
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