4 articles • Expert insights and troubleshooting strategies
Expert insights, best practices, and troubleshooting strategies for successful bioconjugation reactions, including methods to eliminate non-specific binding and optimize conjugation efficiency.
Part 1 of 2: Random conjugation of labels to antibody lysines—is the concern over the impact of CDR modification on antigen binding overstated? The degree of labelling (DoL), defined as the average number of labels per antibody molecule.
Part 2 of 2: Random conjugation of labels to antibody lysines—is the concern over the impact of CDR modification on antigen binding overstated? In part 1, I discussed the distribution of labels after random conjugation.
Antibody–oligonucleotide conjugates have emerged as powerful tools for highly multiplexed and amplified protein detection in imaging and sequencing workflows. Yet when single‑stranded DNA (ssDNA) is conjugated to antibodies, non-specific binding can occur.
Process control strategies for reproducible AOC manufacturing. Learn how tight control of reaction parameters enables consistent production with low coefficient of variation across multiple batches.
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