Random Conjugation

2 articles

Understanding random lysine conjugation for antibody-oligo conjugates, including CDR modification probability, binding impact, and comparison with site-specific methods.

Site-Specific Random Conjugation Therapeutics DAR

Conjugation Chemistry & Methods

Site-Specific vs Random Antibody Conjugation: Methods, Trade-offs, and What Matters Most for the Therapeutic Market

Overview from a practical standpoint, three factors dominate conjugate behaviour: where attachments occur, how many attachments are installed (the degree of labeling (DoL) and the distribution of drug-antibody ratios (DARs).

28 Oct 2025Read article

Advanced Random Conjugation Analysis

Bioconjugation Optimization

Bioconjugation: Tips, Tricks, and Commentary - Part 2

Part 2 of 2: Random conjugation of labels to antibody lysines—is the concern over the impact of CDR modification on antigen binding overstated? In part 1, I discussed the distribution of labels after random conjugation.

21 May 2025Read article

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Tags that appear alongside “Random Conjugation” in articles.

Site-Specific4 Therapeutics1 DAR1 Advanced1 Analysis1